Anaphylaxis is defined as “a serious allergic reaction that is rapid in onset and may cause death”. It typically results in a number of symptoms including throat swelling, an itchy rash, and low blood pressure. Common causes include insect bites, foods, and medications.
On a pathophysiologic level, anaphylaxis is due to the release of mediators from certain types of white blood cells triggered either by immunologic or non-immunologic mechanisms. It is diagnosed based on the presenting symptoms and signs. The primary treatment is injection of epinephrine, with other measures being complementary.